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With the goal of encouraging research independence immediately upon obtaining one's first academic position after receipt of the PhD, the Directorate for Computer and Information Science and Engineering (CISE) will award grants to initiate the course of one's independent research. Understanding the critical role of establishing that independence early in one's career, it is expected that funds will be used to support untenured faculty or research scientists (or equivalent) in their first three years in a primary academic position after the PhD, but not more than a total of five years after completion of their PhD. One may not yet have received any other grants or contracts in the Principal Investigator (PI) role from any department, agency, or institution of the federal government, including from the CAREER program or any other program, post-PhD, regardless of the size of the grant or contract, with certain exceptions noted below. Serving as co-PI, Senior Personnel, Postdoctoral Fellow, or other Fellow does not count against this eligibility rule. Grants, contracts, or gifts from private companies or foundations; state, local, or tribal governments; or universities do not count against this eligibility rule. 

It is expected that these funds will allow the new CISE Research Initiation Initiative PI to support one or more graduate students for up to two years. Faculty at undergraduate and two-year institutions may use funds to support undergraduate students, and may use the additional RUI designation (which requires inclusion of a RUI Impact Statement) -- see for additional information. In addition, submissions from all institutions may use funds for postdoctoral scholars, travel, and/or research equipment.

Category(s): social-science, mathematics, engineering, education, computer-science, health-science, information-science, architecture

CAREER: The Faculty Early Career Development (CAREER) Program is a Foundation-wide activity that offers the National Science Foundation's most prestigious awards in support of early-career faculty who have the potential to serve as academic role models in research and education and to lead advances in the mission of their department or organization. Activities pursued by early-career faculty should build a firm foundation for a lifetime of leadership in integrating education and research. NSF encourages submission of CAREER proposals from early-career faculty at all CAREER-eligible organizations and especially encourages women, members of underrepresented minority groups, and persons with disabilities to apply.
Category(s): social-science, physical-science, mathematics, education, computer-science, life-science, information-science

The Early Career Development and Mentoring program provides support for an integrated research and career development plan for investigators in the early stages of their academic careers who have established an interest in special education research. The ultimate aim of this program is to help launch independent research careers focused on infants, toddlers, children, and youth with or at risk for disabilities. The award will provide support for research (including salary for protected time to conduct research) and career development that includes training under the guidance of an experienced mentor or mentors.
Category(s): social-science, education

A number of NIH Institutes make use of the R03 activity code to issue subject-matter-specific funding opportunities targeted to New Investigators. As with derivative R01s, the specifics of these targeted funding opportunities will vary. Grant specifics (including whether an LOI is required) will vary according to the specific FOA—so read carefully.
Category(s): social-science, physical-science, engineering, education, computer-science, health-science, life-science, information-science

See encouraged topic areas in Solicitation. 

Category(s): mathematics, education

The Department of Defense offers four recurring grant programs that benefit new investigators, including opportunities through the Office of Naval Research (ONR), The Air Force Office of Scientific Research (AFOSR), the Army Research Office (ARO) and the Defense Advanced Research Projects Agency (DARPA). While broad areas of research are supported, the agency will usually evaluate the application in terms of agency need. DoD agencies typically publish lists of desired topic areas.
Category(s): social-science, physical-science, mathematics, engineering, education, computer-science, health-science, life-science, information-science